Functional Coupling of 3-Adrenoceptors and Large Conductance Calcium-Activated Potassium Channels in Human Uterine Myocytes
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چکیده
Some rights reserved. For more information, please see the item record link above. Title Functional coupling of beta(3)-adrenoceptors and large conductance calcium-activated potassium channels in human uterine myocytes 'Functional coupling of beta(3)-adrenoceptors and large conductance calcium-activated potassium channels in human uterine myocytes'.
منابع مشابه
P13: Potassium Channels and Long-Term Potentiation Formation
Long-term potentiation (LTP) is a form of activity-dependent plasticity that occurs during learning. Potassium channels are the most diverse group of all ion channels that related to synaptic plasticity. Small-conductance calcium-activated potassium channels (SKs) are found in hippocampal CA1 neurons and by inhibiting of postsynaptic potentials are involved in synaptic transmission impairment. ...
متن کاملFunctional coupling of beta3-adrenoceptors and large conductance calcium-activated potassium channels in human uterine myocytes.
CONTEXT Beta3-adrenoreceptor modulation in human myometrium during pregnancy is linked functionally to myometrial inhibition. Maxi-K+ channels (BK(Ca)) play a significant role in modulating cell membrane potential and excitability. OBJECTIVE This study was designed to investigate the potential involvement of BK(Ca) channel function in the response of human myometrium to beta3-adrenoceptor act...
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The properties and function of large-conductance calcium- and voltage-activated potassium (BK) channels are modified by the tissue-specific expression of regulatory β1-subunits. Although the short cytosolic N-terminal domain of the β1-subunit is important for controlling both BK channel trafficking and function, whether the same, or different, regions of the N terminus control these distinct pr...
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Small-conductance calcium-activated potassium (SK3) channels have been detected in human myometrium and we have previously shown a functional role of SK channels in human myometrium in vitro. The aims of this study were to identify the precise localization of SK3 channels and to quantify SK3 mRNA expression in myometrium from pregnant and non-pregnant women. Myometrial biopsies were obtained fr...
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